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Human neurologic function and the aging process

A R Potvin, K Syndulko, W W Tourtellotte

    Journal of the American Geriatrics Society
    |January 1, 1980
    PubMed
    Summary
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    Neurologic function significantly declines with age, affecting cognition, motor skills, and senses. This study establishes baseline data for age-matched comparisons in therapeutic evaluations.

    Area of Science:

    • Neurology
    • Gerontology
    • Human Physiology

    Background:

    • Aging is associated with changes in neurologic function.
    • Objective measures are needed to quantify age-related neurologic changes.
    • Understanding these changes is crucial for evaluating interventions.

    Purpose of the Study:

    • To comprehensively assess neurologic function across a wide age range.
    • To establish normative data for age-matched neurologic performance.
    • To identify specific functions most affected by aging.

    Main Methods:

    • 128 instrumented tests of neurologic function administered to 61 men (20-80 years).
    • Tests covered cognition, sensory, motor, and functional abilities.
    • Reliability analysis ensured data integrity; unreliable measures were excluded.

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    Main Results:

    • Significant linear age-related declines observed in most neurologic functions.
    • Declines ranged from <10% to >90% across different functions.
    • Upper extremities showed major declines in steadiness, speed, and vibration sense; lower extremities in balance and vibration sense.

    Conclusions:

    • Age significantly impacts a wide spectrum of neurologic functions.
    • Normative data are essential for evaluating therapeutic interventions.
    • Future research should focus on building comprehensive age- and sex-matched neurologic function databases.