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Related Concept Videos

Chronic Bowel Disorders: Introduction01:17

Chronic Bowel Disorders: Introduction

Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
Drugs for Treatment of Ulcerative Colitis in IBD01:29

Drugs for Treatment of Ulcerative Colitis in IBD

Ulcerative colitis is a chronic inflammatory condition primarily affecting the colon and rectum. The primary drugs used in the treatment of ulcerative colitis are aminosalicylates. They exhibit anti-inflammatory and immunosuppressive properties. They modulate inflammatory mediators and inhibit the activity of nuclear factor κB (NF-κB). Aminosalicylates also reduce inflammation by inhibiting prostaglandin and leukotriene production and decreasing neutrophil chemotaxis and superoxide generation. 
Inflammatory Bowel Disease I: Ulcerative Colitis01:27

Inflammatory Bowel Disease I: Ulcerative Colitis

Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
Inflammatory Bowel Disease I: Introduction01:26

Inflammatory Bowel Disease I: Introduction

Inflammatory bowel disease is a group of chronic disorders marked by recurrent inflammation of the gastrointestinal tract due to an abnormal immune response against gut microflora. This leads to tissue damage. The two main forms are Crohn’s disease and ulcerative colitis.Crohn’s DiseaseCrohn’s disease is a relapsing inflammatory disorder that can affect any part of the GI tract, from the mouth to the anus. It involves all layers of the bowel wall (transmural) and shows “skip lesions” in which...
Inflammatory Bowel Disease II: Ulcerative Colitis01:20

Inflammatory Bowel Disease II: Ulcerative Colitis

Ulcerative colitis is a chronic inflammatory disorder of the colon characterized by continuous mucosal inflammation that typically begins in the rectum and extends proximally in a uniform pattern. Its pathogenesis involves a complex interplay of genetic predisposition, immune dysregulation, and environmental influences. These factors converge to impair the colon’s epithelial defenses and promote an exaggerated inflammatory response against luminal contents.Breakdown of the Mucosal BarrierA...
Inflammatory Bowel Disease IV: Clinical Manifestations01:20

Inflammatory Bowel Disease IV: Clinical Manifestations

Inflammatory bowel disease (IBD) encompasses two major chronic disorders—ulcerative colitis and Crohn’s disease—each characterized by relapsing episodes of gastrointestinal inflammation. Although they share certain clinical features, their patterns of involvement and manifestations differ in ways that aid diagnosis and guide management.Ulcerative ColitisUlcerative colitis is limited to the colon and rectum and involves continuous inflammation of the mucosal layer. The disease course is marked...

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Related Experiment Video

Updated: Jul 13, 2026

A Rat Model of Mild Intrauterine Hypoperfusion with Microcoil Stenosis
06:19

A Rat Model of Mild Intrauterine Hypoperfusion with Microcoil Stenosis

Published on: January 7, 2018

Hepatic infarction in ulcerative colitis during pregnancy

E H Hirsh, J T Galambos, H Armstrong

    Gastroenterology
    |March 1, 1980
    PubMed
    Summary

    A woman experienced acute liver failure during childbirth, leading to hepatic infarctions. She later developed vasculitis and fever, which resolved with prednisone, and was diagnosed with ulcerative colitis.

    Area of Science:

    • Hepatology
    • Gastroenterology
    • Obstetrics

    Background:

    • Acute hepatic failure during parturition is a rare but serious complication.
    • Hepatic infarction, though uncommon, can occur in severe liver injury.
    • The association between pregnancy, liver disease, and inflammatory conditions requires further investigation.

    Observation:

    • A 27-year-old woman presented with acute liver failure coinciding with childbirth.
    • Liver biopsy revealed disseminated hepatic infarctions localized to distal microcirculatory units.
    • Post-infarction, the patient developed persistent fever and cutaneous vasculitis.

    Findings:

    • Prednisone therapy led to the resolution of fever and cutaneous vasculitis.
    • Ulcerative colitis was diagnosed five months after recovery from hepatic failure.

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  • This case highlights a potential link between severe hepatic events in pregnancy and subsequent inflammatory bowel disease.

    • Implications:

    • This case underscores the importance of considering obstetric-related liver complications.
    • Early recognition and management of hepatic infarction and associated vasculitis are crucial.
    • Further research is needed to explore the potential pathogenesis linking pregnancy-related liver failure, vasculitis, and ulcerative colitis.