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Amelanotic lentigo maligna

W P Su, R R Bradley

    Archives of Dermatology
    |January 1, 1980
    PubMed
    Summary
    This summary is machine-generated.

    Amelanotic lentigo maligna, a rare skin cancer variant, can mimic dermatitis. Biopsying any changing lesion site after treatment is crucial for early detection of this non-pigmented melanoma.

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    Area of Science:

    • Dermatology
    • Oncology
    • Pathology

    Background:

    • Lentigo maligna is a slow-growing melanoma in situ.
    • Complete excision is the standard treatment.
    • Post-treatment surveillance is essential for recurrence or new primary lesions.

    Observation:

    • A 68-year-old woman developed a dermatitis-like lesion at the site of a previously excised pigmented lentigo maligna.
    • The lesion was hypopigmented with irregular erythema.
    • Clinical diagnosis was neurodermatitis.

    Findings:

    • Biopsy revealed amelanotic lentigo maligna, lacking melanin pigmentation.
    • This represents the first reported case of amelanotic lentigo maligna presenting with a dermatitis-like appearance.
    • The lesion evolved over a seven-year follow-up period.

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    Implications:

    • Amelanotic lentigo maligna can present atypically, mimicking inflammatory skin conditions.
    • Biopsy is recommended for any clinically changing lesion site after lentigo maligna treatment, regardless of pigmentation.
    • This case highlights the importance of histological confirmation in diagnosing challenging skin lesions.