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Sterile hypopyon following intraocular lens surgery
Archives of Ophthalmology (Chicago, Ill. : 1960)
|January 1, 1980
Summary
Residual polishing compound on intraocular lenses may cause sterile hypopyon. Energy-dispersive x-ray analysis (EDXA) detected this compound and barium crystals on lenses, suggesting potential surgical complications.
Area of Science:
- Ophthalmology
- Materials Science
- Analytical Chemistry
Background:
- Sterile hypopyon is a serious complication following intraocular lens (IOL) surgery.
- The etiology of sterile hypopyon is not fully understood.
- Contamination of IOLs during manufacturing or sterilization is a potential factor.
Purpose of the Study:
- To investigate the surface composition of intraocular lenses (IOLs) associated with sterile hypopyon.
- To identify potential contaminants that could trigger an inflammatory response.
Main Methods:
- Energy-dispersive x-ray analysis (EDXA) was employed to examine the surface of nine IOLs from a single manufacturer.
- Lenses included dry-sterilized and wet-sterilized samples, some from a "hot lot" with high hypopyon incidence.
Main Results:
- Residual polishing compound was identified on two of three dry-sterilized lenses from the affected "hot lot".
- This compound was fused to the lens surface, resisting ultrasonic cleaning.
- Barium-containing crystals, likely from glass vial leaching, were found on three wet-sterilized lenses.
Conclusions:
- Residual polishing compound on IOL surfaces is a potential cause of sterile hypopyon.
- Contamination from manufacturing or storage materials may lead to post-operative inflammation.
- EDXA is a valuable tool for identifying contaminants on medical devices.