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Related Experiment Videos

Studies on infertility in males

A A Fattah, A A Azim, M Habeib

    Fertility and Sterility
    |February 1, 1980
    PubMed
    Summary
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    Spermagglutinating antibodies were found in 28% of infertile men, with a correlation to serum autoantibody titers. This suggests a link between infections and the presence of these antibodies, impacting male fertility.

    Area of Science:

    • Reproductive Immunology
    • Andrology
    • Immunology

    Background:

    • Male infertility is a significant concern.
    • Autoantibodies against sperm may contribute to infertility.
    • Genital tract infections and schistosomiasis are potential contributing factors.

    Purpose of the Study:

    • To investigate the prevalence of circulating spermagglutinating antibodies in infertile men.
    • To explore the correlation between autoantibody titers and sperm agglutination.
    • To identify the presence of sperm-immobilizing antibodies.

    Main Methods:

    • Kibrick spermagglutination test was used to detect antibodies.
    • Sera from 115 infertile men were analyzed.
    • Agglutination titers and microscopic agglutination percentages were recorded.
    Keywords:
    Antibodies--analysisBiologyGenitaliaGenitalia, MaleImmunityImmunologic FactorsInfectionsInfertility--etiologyInfertility--menPhysiologyReproductionSemen--analysisSeminal VesiclesSperm CountSperm TransportUrogenital System

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    Main Results:

    • 28% of men (33 out of 115) showed positive spermagglutinating antibody titers (≥1:32).
    • A positive correlation was observed between serum autoantibody titer and spermagglutination.
    • Sperm-immobilizing antibodies were detected in 6.9% of cases.

    Conclusions:

    • Elevated levels of spermagglutinating antibodies are present in a significant portion of infertile men.
    • Genital tract infections and urinary schistosomiasis may contribute to the high incidence of these antibodies.
    • The findings suggest a role for sperm antibodies in male infertility.