Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

C3 polymorphism in patients with chronic uremia

E Stoffersen, K A Jørgensen

    Human Heredity
    |January 1, 1980
    PubMed
    Summary

    The C3 polymorphism C3F and C3FS phenotypes were less common in patients with chronic pyelonephritis compared to those with chronic glomerulonephritis or healthy individuals. This finding may indicate a genetic link to kidney disease progression.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    The impact of calcineurin inhibitors on insulin sensitivity and insulin secretion: a randomized crossover trial in uraemic patients.

    Diabetic medicine : a journal of the British Diabetic Association·2012
    Same author

    Abnormal diurnal rhythm of urine output following renal transplantation: the impact of blood pressure and diuretics.

    Transplantation proceedings·2010
    Same author

    Cyclosporin and tacrolimus impair insulin secretion and transcriptional regulation in INS-1E beta-cells.

    British journal of pharmacology·2010
    Same author

    Gene expression analysis of calcineurin isoforms in T-lymphocytes--a method applied on kidney-transplant recipients.

    Transplant immunology·2010
    Same author

    A combined experimental and theoretical study on realizing and using laser controlled torsion of molecules.

    The Journal of chemical physics·2009
    Same author

    NT-pro-BNP is an independent predictor of mortality in patients with end-stage renal disease.

    Clinical nephrology·2009

    Area of Science:

    • Nephrology
    • Immunogenetics
    • Clinical Chemistry

    Background:

    • Complement component 3 (C3) is a key protein in the immune system.
    • C3 polymorphism influences complement system activity and may be associated with various diseases.
    • Chronic kidney diseases, including uremia, pyelonephritis, and glomerulonephritis, have complex etiologies.

    Purpose of the Study:

    • To investigate the distribution of C3 polymorphism phenotypes in patients with chronic uremia undergoing maintenance hemodialysis.
    • To compare the frequencies of C3F and C3FS phenotypes between patients with chronic pyelonephritis and chronic glomerulonephritis.

    Main Methods:

    • High-voltage agarose gel electrophoresis was used to determine C3 polymorphism phenotypes.
    • The study included 83 patients with chronic uremia on maintenance hemodialysis.
    • Phenotype frequencies were compared between subgroups (chronic pyelonephritis, chronic glomerulonephritis) and a control group.

    Main Results:

    • The frequency of C3F and C3FS phenotypes was significantly lower in 45 patients with chronic pyelonephritis compared to 38 patients with chronic glomerulonephritis.
    • This lower frequency was also observed when compared to a large control group.
    • No specific phenotype distribution was detailed for the entire cohort of 83 uremic patients, but comparisons were made between disease groups.

    Conclusions:

    • The findings suggest a potential association between lower frequencies of C3F and C3FS phenotypes and chronic pyelonephritis.
    • This may indicate a protective role or different genetic predisposition in the pathogenesis of chronic pyelonephritis compared to chronic glomerulonephritis.
    • Further research is warranted to elucidate the role of C3 polymorphism in the development and progression of different types of chronic kidney disease.

    Related Experiment Videos