Spinal cord stimulation in multiple sclerosis: clinical results

Area of Science:

• Neurology
• Rehabilitation Medicine

Background:

• Multiple sclerosis (MS) is a chronic neurological disease affecting the central nervous system.
• Spinal cord stimulation (SCS) is an emerging therapy for managing neurological conditions.

Purpose of the Study:

• To evaluate the clinical outcomes of spinal cord stimulation in patients with multiple sclerosis.
• To assess the efficacy of SCS in improving mobility, sensory function, and bladder control in MS patients.

Main Methods:

• Nineteen patients with multiple sclerosis received temporary percutaneous epidural electrode stimulation.
• Clinical responses were assessed for mobility, sensory function, upper limb ataxia, and bladder function.
• Cystometry was performed on a subset of patients with severe bladder disturbance.

Main Results:

• Significant improvements in mobility (27.7%) and sensory function (27.7%) were observed in temporary stimulation.
• Bladder function showed the most substantial improvement, with 75% of patients experiencing benefits.
• Medium-term follow-up (up to two years) indicated sustained improvements in bladder function and mobility.

Conclusions:

• Spinal cord stimulation can lead to worthwhile clinical responses in multiple sclerosis patients, particularly for bladder dysfunction.
• The type of stimulation, not merely its presence, influences patient response, suggesting a specific physiological mechanism.
• SCS offers a promising therapeutic option for managing specific symptoms in multiple sclerosis.