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Renal failure associated with fenoprofen

M L Wendland, R D Wagoner, K E Holley

    Mayo Clinic Proceedings
    |February 1, 1980
    PubMed
    Summary
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    Nonsteroidal anti-inflammatory drugs can harm kidney function. Two patients developed acute renal failure, tubulointerstitial nephritis, and nephrotic syndrome due to fenoprofen, which resolved upon drug cessation.

    Area of Science:

    • Nephrology
    • Pharmacology
    • Rheumatology

    Background:

    • Nonsteroidal anti-inflammatory drugs (NSAIDs) are widely used for arthritis.
    • NSAIDs have been linked to adverse renal effects.
    • Fenoprofen is an NSAID used to manage arthritic conditions.

    Observation:

    • Two patients presented with acute renal failure.
    • The renal failure was associated with tubulointerstitial nephritis and nephrotic syndrome.
    • Fenoprofen use was identified as the likely cause.

    Findings:

    • Fenoprofen-induced acute renal failure can manifest with tubulointerstitial nephritis and nephrotic syndrome.
    • Discontinuation of fenoprofen led to the resolution of renal complications.
    • This suggests a direct, reversible nephrotoxic effect of fenoprofen.

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    Implications:

    • Clinicians should consider fenoprofen as a potential cause of acute kidney injury in patients with arthritis.
    • Monitoring renal function in patients taking fenoprofen is crucial.
    • NSAID-induced nephrotoxicity highlights the importance of judicious drug use and patient monitoring.