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Related Experiment Videos

Left-handed DNA helices

S Arnott, R Chandrasekaran, D L Birdsall

    Nature
    |February 21, 1980
    PubMed
    Summary
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    X-ray diffraction revealed that synthetic DNA with alternating purine-pyrimidine sequences can form novel, well-known A or B-form structures. This finding expands our understanding of DNA conformation possibilities.

    Area of Science:

    • Molecular Biology
    • Biophysics
    • Structural Biology

    Background:

    • Synthetic DNA polymers are crucial models for studying DNA structure and function.
    • The double helix exists in various conformations, including A-form and B-form, influenced by sequence and environment.

    Purpose of the Study:

    • To investigate the structural conformations of the synthetic DNA polymer poly d(GC) . poly d(GC).
    • To determine if this polymer adopts known DNA structures or novel ones.

    Main Methods:

    • X-ray diffraction was used on oriented fibers of the synthetic DNA polymer.
    • Analysis focused on identifying the characteristic diffraction patterns corresponding to specific DNA conformations.

    Main Results:

    Related Experiment Videos

  • The synthetic DNA polymer poly d(GC) . poly d(GC) was observed to adopt either the A-form or B-form conformation.
  • Similar conformations were noted in other alternating purine-pyrimidine sequences like poly d(AC) . poly d(GT) and poly d(As4T) . poly d(As4T).

    • Conclusions:

    • Alternating purine-pyrimidine DNA sequences are capable of forming well-established A and B-form structures.
    • The study demonstrates the accessibility of these common DNA structures to a broad range of synthetic DNA segments with specific base sequences.