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Assessment and Evaluation of the High Risk Neonate: The NICU Network Neurobehavioral Scale
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Published on: August 25, 2014

Angel dust: possible effects on the fetus

N L Golden, R J Sokol, I L Rubin

    Pediatrics
    |January 1, 1980
    PubMed

    Insights

    This case report details an infant exposed to phencyclidine (PCP) during pregnancy, exhibiting abnormal neonatal behavior, dysmorphology, and spastic quadriparesis. Further research is needed to confirm the link between prenatal PCP exposure and these developmental outcomes.

    Area of Science:

    • Neonatal Abstinence Syndrome
    • Developmental Toxicology
    • Neurodevelopmental Disorders

    Background:

    • Prenatal exposure to substances of abuse is a significant concern.
    • Phencyclidine (PCP), a dissociative anesthetic, has known neurotoxic effects.
    • Limited data exists on the long-term effects of prenatal PCP exposure in humans.

    Observation:

    • A neonate presented with abnormal behavior and dysmorphology after maternal phencyclidine (PCP) use during pregnancy.
    • The infant later developed spastic quadriparesis.
    • Neonatal behaviors were consistent with known effects of PCP.

    Findings:

    • The infant likely experienced prolonged fetal exposure to PCP.
    • A potential association between prenatal PCP exposure and the infant's dysmorphology and spasticity is suggested.
    • The precise relationship remains speculative and requires further investigation.

    Implications:

    • Clinicians should be vigilant for similar presentations in infants with prenatal PCP exposure.
    • This case highlights the potential teratogenic effects of PCP.
    • Further research is warranted to elucidate the full spectrum of developmental outcomes associated with prenatal PCP exposure.

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