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Significance of a sixth lactate dehydrogenase isoenzyme (LDH6)
American Journal of Clinical Pathology
|February 1, 1980
Insights
An unusual lactate dehydrogenase (LDH) band was detected in blood samples from 18 patients, with most experiencing poor outcomes. This electrophoretic finding, though its cause remains unknown, was associated with severe cardiovascular and liver conditions.
Area of Science:
- Clinical Biochemistry
- Diagnostic Medicine
- Hematology
Background:
- Lactate dehydrogenase (LDH) electrophoresis is a diagnostic tool.
- Unexplained electrophoretic findings can indicate underlying pathology.
- Patient outcomes are crucial in interpreting diagnostic results.
Purpose of the Study:
- To report an unusual finding on lactate dehydrogenase (LDH) electrophoresis.
- To investigate the clinical significance of a unique LDH band.
- To correlate this electrophoretic abnormality with patient conditions and outcomes.
Main Methods:
- Blood specimens from 18 patients were analyzed.
- Lactate dehydrogenase (LDH) electrophoresis was performed.
- Clinical data, including diagnoses and outcomes, were reviewed.
Main Results:
- An unusual band was consistently observed on the cathodic side of the membrane during LDH electrophoresis.
- Fifteen of the 18 patients with this band died shortly after its detection.
- The specific cause of the unique LDH band was not identified.
- Most affected patients had a history of arteriosclerotic cardiovascular disease, acute passive liver hyperemia, and prerenal azotemia.
Conclusions:
- The presence of an unusual cathodic LDH band may be a marker for severe underlying disease.
- This electrophoretic abnormality is associated with poor prognosis, particularly in patients with cardiovascular and hepatic compromise.
- Further research is needed to elucidate the exact cause and implications of this LDH finding.
Abstract:
An unusual band on the cathodic side of the membrane was found on lactate dehydrogenase electrophoresis of blood specimens from 18 patients. Fifteen patients died shortly after the finding. No specific cause was found for the unique band, but most of the patients had arteriosclerotic cardiovascular disease with acute passive hyperemia of the liver, and prerenal azotemia.