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Related Experiment Videos

Asthma induced by enkephalin

R D Leslie, D Bellamy, D A Pyke

    British Medical Journal
    |January 5, 1980
    PubMed
    Summary
    This summary is machine-generated.

    Facial flushing in diabetics after chlorpropamide and alcohol may indicate asthma. This reaction appears mediated by endogenous peptides with opiate-like activity, such as enkephalin.

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    Area of Science:

    • Pharmacology
    • Immunology
    • Endocrinology

    Background:

    • Investigating the link between chlorpropamide-alcohol flushing and asthmatic reactions in diabetic patients.
    • Assessing the prevalence of breathlessness and wheezing in patients experiencing facial flushing.

    Observation:

    • Out of 291 diabetics, 191 reported facial flushing after chlorpropamide and alcohol.
    • Twelve of these patients also experienced breathlessness, with five exhibiting wheezing and confirmed asthma via respiratory function tests.

    Findings:

    • Asthma induced by chlorpropamide and alcohol flushing is linked to endogenous peptides with opiate-like activity.
    • Disodium cromoglycate and naloxone prevented the asthmatic reaction in three patients.
    • An enkephalin analogue triggered wheezing in one patient, supporting the opiate-like peptide hypothesis.

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    Implications:

    • Suggests a potential mechanism for drug-induced asthma mediated by endogenous opioid systems.
    • Highlights the importance of considering non-allergic hypersensitivity reactions in diabetic patients.
    • Informs potential therapeutic strategies targeting opioid pathways for managing such reactions.