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Heterotrophic nitrification by intestinal microorganisms

R F Gomez, S R Tannenbaum, J Savoca

    Cancer
    |March 15, 1980
    PubMed
    Summary
    This summary is machine-generated.

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    Intestinal microbes can create nitrite and nitrate, altering our understanding of exposure and potentially linking to intestinal cancer. This process, known as heterotrophic nitrification, involves both bacteria and other microorganisms.

    Area of Science:

    • Microbiology
    • Human Physiology
    • Gastroenterology

    Background:

    • Nitrate and nitrite balance in humans is incompletely understood.
    • The intestine's role in nitrogen compound metabolism is a key area of research.
    • Potential endogenous sources of nitrite and nitrate require investigation.

    Purpose of the Study:

    • To investigate the possibility of de novo nitrite and nitrate formation in the human intestine.
    • To explore the role of heterotrophic nitrification by intestinal microbes.
    • To assess the implications for human exposure to nitrite and potential links to intestinal cancer.

    Main Methods:

    • Analysis of fecal and ileostomy samples.
    • Isolation and characterization of intestinal microorganisms.

    Related Experiment Videos

  • Demonstration of nitrogenous compound oxidation by microbial isolates.

    • Main Results:

    • Evidence suggests de novo formation of nitrite and nitrate in the intestine.
    • Intestinal microbial isolates, including procaryotes and eucaryotes, were shown to perform heterotrophic nitrification.
    • These microbes can oxidize nitrogenous compounds to nitrite.

    Conclusions:

    • Heterotrophic nitrification by intestinal microbes is a plausible source of endogenous nitrite and nitrate.
    • This finding necessitates a re-evaluation of human exposure pathways to nitrite.
    • The endogenous production of nitrite may have implications for intestinal cancer risk.