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Gap junctions on myoepithelial cells

R Taugner, A Schiller

    Cell and Tissue Research
    |January 1, 1980
    PubMed
    Summary
    This summary is machine-generated.

    Myoepithelial cells in male mouse submandibular glands connect via gap junctions. These junctions are crucial for synchronizing the contractile functions of these cells throughout the gland.

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    Area of Science:

    • Glandular Biology
    • Cellular Physiology
    • Histology

    Background:

    • Myoepithelial cells are specialized contractile cells surrounding secretory units and ducts in exocrine glands.
    • Their distribution and function within the submandibular gland, particularly around striated ducts, require further elucidation.
    • Understanding cell-cell communication is vital for comprehending gland function.

    Purpose of the Study:

    • To investigate the precise location of myoepithelial cells within the male mouse submandibular gland.
    • To determine the presence and nature of connections between myoepithelial cells and their processes.
    • To explore the potential functional significance of these connections.

    Main Methods:

    • Histological examination of male mouse submandibular glands.

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  • Immunohistochemistry to identify myoepithelial cells.
  • Electron microscopy to visualize cell junctions.

    • Main Results:

    • Myoepithelial cells were identified not only around endpieces and intercalated ducts but also surrounding striated ducts.
    • Gap junctions were observed connecting myoepithelial cells and their processes, irrespective of their location.
    • These findings indicate a widespread network of interconnected myoepithelial cells.

    Conclusions:

    • Myoepithelial cells in the male mouse submandibular gland exhibit a broader distribution than previously recognized, extending around striated ducts.
    • The presence of gap junctions suggests direct cell-to-cell communication pathways.
    • These gap junctions are hypothesized to synchronize the contractile activity of myoepithelial cells, impacting gland secretion.