Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Proliferative function of cadaveric bone marrow cells

P I Liu, M Ogawa, L Crook

    American Journal of Hematology
    |January 1, 1978
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    A high-sensitivity enzyme-linked immunosorbent assay for serum thyroglobulin.

    Thyroid : official journal of the American Thyroid Association·2001
    Same author

    Recovered memories of childhood abuse. There is no evidence that therapists implant memories.

    BMJ (Clinical research ed.)·1998
    Same author

    Stimulation of hematopoiesis by amifostine in patients with myelodysplastic syndrome.

    Blood·1997
    Same author

    Fatal suture embolism to the left anterior descending coronary artery. A case report and review of the literature.

    The American journal of forensic medicine and pathology·1994
    Same author

    [Present status and clinical therapy of pancreatic diseases].

    Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine·1992
    Same author

    Reptilian viruses: adenovirus-like agent isolated from royal python (Python regius).

    Zentralblatt fur Veterinarmedizin. Reihe B. Journal of veterinary medicine. Series B·1992
    Same journal

    Signaling Mutations Negate the Favorable Impact of NPM1 Mutations in Older Patients With Newly Diagnosed Acute Myeloid Leukemia Treated With VEN/HMA.

    American journal of hematology·2026
    Same journal

    Comparative Efficacy of Intranasal, Intramuscular, and Intravenous Vitamin B12 Therapy for Hematological Recovery in Vitamin B12 Deficiency Anemia: A Randomized Controlled Trial.

    American journal of hematology·2026
    Same journal

    Clinical Predictors of Response in Chronic Graft-Versus-Host Disease: Results From the "Predicting the Quality of Response to Specific Treatments (PQRST)" Trial.

    American journal of hematology·2026
    Same journal

    Relapse Thresholds (12/24 Mo) Define Survival Disparity in Pediatric B-ALL.

    American journal of hematology·2026
    Same journal

    Quizartinib in Combination With FLAG-IDA for Relapsed or Refractory Acute Myeloid Leukemia (FLAG-QUIDA): A PETHEMA Phase I-II Trial.

    American journal of hematology·2026
    Same journal

    Defining a Subgroup of Myelodysplastic Syndrome Patients With Very Poor-Risk Cytogenetics Demonstrating a Relatively More Favorable Outcome After Allogeneic Hematopoietic Cell Transplantation.

    American journal of hematology·2026
    See all related articles

    Human and murine cadaveric bone marrow retains hematopoietic stem cell function for up to 19 hours postmortem. This suggests pluripotent hematopoietic stem cells can survive in cadaveric bone marrow.

    Area of Science:

    • Hematology
    • Stem Cell Biology
    • Postmortem Studies

    Background:

    • Understanding the viability of hematopoietic stem cells (HSCs) in postmortem tissue is crucial for transplantation and research.
    • Previous studies have limited data on the functional persistence of HSCs after death.

    Purpose of the Study:

    • To investigate the proliferative capacity and survival of hematopoietic stem cells in human and murine cadaveric bone marrow.
    • To determine the duration for which hematopoietic functions persist postmortem.

    Main Methods:

    • Utilized methylcellulose clonal cell culture assays to assess cell proliferation.
    • Employed the murine spleen colony technique to evaluate stem cell function in vivo.
    • Examined both human and murine cadaveric bone marrow samples.

    Related Experiment Videos

    Main Results:

    • Demonstrated the persistence of hematopoietic functions in cadaveric bone marrow for up to 19 hours postmortem in some cases.
    • Observed consistent findings between human and murine cadaveric bone marrow studies.
    • Confirmed the proliferative capacity of stem cells in postmortem samples.

    Conclusions:

    • Human pluripotent hematopoietic stem cells exhibit remarkable survival capabilities in cadaveric bone marrow.
    • Cadaveric bone marrow can potentially serve as a source of viable hematopoietic stem cells for a limited postmortem period.
    • These findings have implications for bone marrow transplantation and regenerative medicine research.