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Pseudomyxoma peritonei

R N Fernandez, J M Daly

    Archives of Surgery (Chicago, Ill. : 1960)
    |April 1, 1980
    PubMed
    Summary
    This summary is machine-generated.

    Pseudomyxoma peritonei treatment combining surgery with radiotherapy offers improved survival rates compared to chemotherapy. Effective tumor reduction and omentectomy are crucial initial surgical steps for this rare cancer.

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    Area of Science:

    • Oncology
    • Surgical Oncology

    Background:

    • Pseudomyxoma peritonei is a rare malignancy.
    • Treatment outcomes for pseudomyxoma peritonei have historically varied.

    Purpose of the Study:

    • To evaluate the survival rates and efficacy of different treatment regimens for pseudomyxoma peritonei.
    • To identify optimal surgical and adjunct treatment strategies.

    Main Methods:

    • Retrospective analysis of 38 patients treated between 1954 and 1978.
    • Comparison of survival rates based on surgical interventions, chemotherapy (fluorouracil, melphalan), and radiotherapy.

    Main Results:

    • Actuarial survival rates were 54% at five years and 18% at ten years.
    • Adjunctive radiotherapy alone showed a 75% five-year survival rate, compared to 44% for chemotherapy.

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  • Local or regional disease caused death in 68% of patients; no metastatic death occurred.

    • Conclusions:

    • Initial surgery should involve tumor reduction, omentectomy, appendectomy, and oophorectomy in females.
    • Radiotherapy may offer improved survival for pseudomyxoma peritonei compared to chemotherapy.
    • Further research into multimodal treatment approaches is warranted.