Related Experiment Video

Updated: Oct 30, 2025

Biosensor-based High Throughput Biopanning and Bioinformatics Analysis Strategy for the Global Validation of Drug-protein Interactions
08:31

Biosensor-based High Throughput Biopanning and Bioinformatics Analysis Strategy for the Global Validation of Drug-protein Interactions

Published on: December 1, 2020

5.2K

The role of biochemistry in drug research

V Stefanovich

    Current Medical Research and Opinion
    |January 1, 1980
    PubMed

    More Related Videos

    A Manual Small Molecule Screen Approaching High-throughput Using Zebrafish Embryos07:45

    A Manual Small Molecule Screen Approaching High-throughput Using Zebrafish Embryos

    Published on: November 8, 2014

    17.9K
    Free Radicals in Chemical Biology: from Chemical Behavior to Biomarker Development14:22

    Free Radicals in Chemical Biology: from Chemical Behavior to Biomarker Development

    Published on: April 15, 2013

    20.5K

    Related Concept Videos

    Drug Discovery: Overview01:26

    Drug Discovery: Overview

    Drug discovery is a multifaceted process involving extensive screening, testing, and optimization of lead compounds to identify potential new drugs for therapeutic use. It combines several approaches, including screening large numbers of natural products, chemical modification of known active molecules, identification of new drug targets, and rational design based on biological mechanisms and drug-receptor structure. These approaches are carried out in both academic research laboratories and...
    10.1K
    Structure-Activity Relationships and Drug Design01:28

    Structure-Activity Relationships and Drug Design

    Drug design is a dynamic field that involves discovering and developing new medications based on specific biological targets. This process heavily relies on structure-activity relationships (SAR) and quantitative structure-activity relationships (QSAR) to guide the design and optimization of efficient drugs.
    SAR studies the intricate relationship between a drug's chemical structure and biological activity. It focuses on understanding how modifications to a drug's structure can influence...
    1.2K
    Drug Biotransformation: Overview01:28

    Drug Biotransformation: Overview

    Biotransformation, also known as drug metabolism, is a vital physiological process that chemically alters drugs, facilitating their elimination from the body and terminating their action. This process involves two main phases: phase I and phase II reactions. Phase I reactions, including oxidation, reduction, and hydrolysis, introduce or unmask polar functional groups on the drug molecule, thereby increasing its water solubility. By enhancing water solubility, the drug becomes more hydrophilic...
    1.9K
    Drug Biotransformation: Overview01:16

    Drug Biotransformation: Overview

    Pharmaceutical substances known as xenobiotics are predominantly lipophilic and nonionized. This enables them to permeate lipid bilayers, such as cell membranes, and interact with intracellular target receptors. Lipophilic drugs have an advantage in crossing biological barriers and reaching their intended sites of action. However, lipophilic drugs often have a restricted capacity for renal expulsion or elimination from the body. When these drugs enter the kidneys and undergo glomerular...
    3.2K
    Factors Affecting Drug Biotransformation: Physicochemical and Chemical Properties of Drugs01:21

    Factors Affecting Drug Biotransformation: Physicochemical and Chemical Properties of Drugs

    A drug's physicochemical properties fundamentally influence its metabolism. For instance, a drug's molecular size and shape critically determine its interaction with enzymes and transporters — larger drugs may face difficulty reaching enzyme active sites, altering their metabolic pathways. The pKa of a drug, which establishes its ionization state, can impact its solubility and absorption, thereby influencing metabolism.
    The drug's acidity or basicity is essential in...
    522
    Biopharmaceutics and Pharmacokinetics: Overview01:28

    Biopharmaceutics and Pharmacokinetics: Overview

    Understanding drugs, drug products, and their performance in pharmaceutical science is pivotal. Drugs, whether simple molecules or complex compounds, are designed to interact with the body's biological systems to diagnose, treat, or prevent diseases. Drug products include various delivery systems such as tablets, capsules, injections, and inhalers. The performance of these drug products is gauged by their ability to deliver the active ingredient to the desired site of action at the...
    2.8K