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Related Experiment Videos

Delayed cutaneous reaction to phytonadione

J W Robison, R B Odom

    Archives of Dermatology
    |December 1, 1978
    PubMed
    Summary

    A patient experienced a delayed skin reaction after receiving phytonadione (vitamin K) injections. Patch tests confirmed sensitivity specifically to phytonadione, not other preparation components.

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    Area of Science:

    • Dermatology
    • Pharmacology

    Background:

    • Phytonadione (vitamin K) is commonly administered via intramuscular injection.
    • Cutaneous reactions to pharmaceutical preparations can occur.

    Observation:

    • A 63-year-old male presented with a delayed hypersensitivity reaction at injection sites.
    • The reaction occurred following intramuscular administration of a phytonadione preparation.

    Findings:

    • Intradermal and epicutaneous testing were performed using the drug and its constituents.
    • Patch testing confirmed specific sensitivity to pure phytonadione.
    • No sensitivity was detected for other components within the phytonadione preparation.

    Implications:

    • This case highlights phytonadione as a potential allergen causing delayed cutaneous reactions.
    • Understanding specific component sensitivity is crucial for managing adverse drug reactions.
    • Further investigation into phytonadione hypersensitivity may be warranted.

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