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Related Experiment Videos

Progressive interstitial lung disease from prolonged methotrexate therapy

R L Kaplan, D H Waite

    Archives of Dermatology
    |December 1, 1978
    PubMed
    Summary
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    Methotrexate therapy for psoriasis can lead to progressive interstitial lung disease, characterized by fibrosis and honeycombing. Discontinuing methotrexate improved lung function and gas exchange in a long-term patient.

    Area of Science:

    • Pulmonology
    • Dermatology
    • Pharmacology

    Background:

    • Methotrexate is a common treatment for psoriasis.
    • Long-term methotrexate use can have various side effects.

    Observation:

    • A psoriatic patient on methotrexate for 18 years developed progressive interstitial lung fibrosis with honeycombing.
    • Pulmonary function tests showed restrictive and obstructive defects with impaired gas transfer.

    Findings:

    • Discontinuation of methotrexate therapy led to improvement in arterial blood gases.
    • Pulmonary diffusing capacity also improved after stopping methotrexate.

    Implications:

    • Interstitial lung disease is a potential serious complication of long-term methotrexate treatment for psoriasis.

    Related Experiment Videos

  • Monitoring pulmonary function in patients on long-term methotrexate is crucial.
  • Methotrexate-induced lung disease may be reversible upon drug cessation.