Suppression of lymphocyte PHA-responsiveness after rubella vaccination with Cendehill and RA 27/3 strains

Two rubella vaccine strains, Cendehill and RA 27/3, were compared with regard to their immunosuppressive effect in vivo. 26 female vaccinees were studied. Both vaccines caused a slight transient suppression of lymphocyte responsiveness to mitogens on day 11 after vaccination. A whole blood culture method was used for lymphocyte stimulation tests, and the method appeared suitable for clinical studies of cell-mediated immunity.