[Changes in the endometrium from the use of hormonal preparations and hormonal contraceptives]

The paper analyses changes in the uterine mucosa caused by the use of hormone drugs, including hormonal contraceptives and studied by light and electron microscopy. Special emphasis is given to changes caused by overdosage of the drugs. Long-term usage of estrogens and progesterone, both separately and particularly in combination, results in marked atrophy and slcerosis of not only uterine mucosa but also of the uterus itself. In women over 35, a long-term oral use of hormonal contraceptives may lead to the development of thromboses and thromboembolias. Therapeutic suggestions are given for different changes of the mucosa revealed by histological studies. A reliable diagnosis should be based on both morphological and functional aspects.