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Related Experiment Videos

Two new artifacts in automated coagulation testing

S I Gutman, P Didisheim, H Markowitz

    American Journal of Clinical Pathology
    |April 1, 1980
    PubMed
    Summary
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    Two Sherwood Lancer Coagulyzer artifacts, related to prothrombin time and activated partial thromboplastin time, may reveal critical patient information like low fibrinogen or hypoalbuminemia, aiding early diagnosis.

    Area of Science:

    • Clinical Chemistry
    • Hematology
    • Medical Laboratory Science

    Background:

    • Routine use of the Sherwood Lancer Coagulyzer identified two distinct artifacts.
    • These artifacts involved discrepancies in prothrombin time (PT) and activated partial thromboplastin time (aPTT) results compared to reference methods.

    Purpose of the Study:

    • To investigate two artifacts observed during routine use of the Sherwood Lancer Coagulyzer.
    • To determine the clinical significance and potential diagnostic value of these artifacts.

    Main Methods:

    • Analysis of prothrombin times and activated partial thromboplastin times using the Sherwood Lancer Coagulyzer and reference instruments.
    • Continuous optical density tracings during clotting assays.
    • In vitro correction studies for identified patient conditions.

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    Main Results:

    • Artifact 1: Prolonged PTs in 44 patients with subnormal fibrinogen, indicated by low optical density slopes/amplitudes. 24 patients died, 20 within 3 weeks.
    • Artifact 2: Spurious short aPTTs in 12 patients with hypoalbuminemia and elevated IgM. Artifact resolved with in vitro albumin correction in 7 patients.

    Conclusions:

    • The observed artifacts are not instrument weaknesses but potential indicators of significant clinical conditions.
    • These findings suggest the Sherwood Lancer Coagulyzer artifacts may provide early warnings for critical laboratory information, including low fibrinogen and hypoalbuminemia.