The Torre syndrome with gastrointestinal polyposis

Area of Science:

• Dermatology
• Gastroenterology
• Oncology

Background:

• Torre syndrome is characterized by the association of multiple cutaneous sebaceous neoplasms with internal malignancies, predominantly gastrointestinal (GI) tract cancers.
• While GI tract carcinoma is established in Torre syndrome, the presence of multiple GI polyps has not been previously recognized.

Observation:

• A case study of a 75-year-old man presenting with multiple sebaceous adenomas, sebaceous epitheliomas, and keratoacanthomas.
• The patient also exhibited multiple colonic polyps, with one lesion confirmed as adenocarcinoma upon histological examination.

Findings:

• The co-occurrence of multiple cutaneous sebaceous neoplasms and multiple colonic polyps, including adenocarcinoma, in this patient.
• This observation expands the recognized spectrum of gastrointestinal manifestations associated with Torre syndrome.

Implications:

• Suggests a potential link between multiple sebaceous neoplasms and a broader range of gastrointestinal pathology, including polyposis.
• Highlights the importance of thorough gastrointestinal evaluation in patients diagnosed with Torre syndrome.
• May prompt further research into the underlying mechanisms connecting cutaneous sebaceous tumors and gastrointestinal polyps/cancers.