Denervation produces supersensitivity of a serotonergically innervated structure

The lateral ciliated gill epithelium of Mytilus edulis was denervated physically and chemically with 5,6-dihydroxytryptamine. Lateral ciliary activity which is under excitatory serotonergic control displayed an increased response to superfusion with serotonin after both treatment, as compared to controls. Endogenous serotonin levels were reduced by these treatments. An increase in maximal cilioexcitatory response was also noted.