Solvent isotope effects on tautomerization equilibria of papain and model thiolamines

Glyoxalase I inhibitors in cancer chemotherapy.

Biochemical Society transactions·2003

Brief history of glyoxalase I and what we have learned about metal ion-dependent, enzyme-catalyzed isomerizations.

Archives of biochemistry and biophysics·2001

Role of hydrophobic interactions in binding S-(N-aryl/alkyl-N-hydroxycarbamoyl)glutathiones to the active site of the antitumor target enzyme glyoxalase I.

Journal of medicinal chemistry·2000

Reaction of COTC with glutathione: structure of the putative glyoxalase I inhibitor.

Organic letters·2000

Pharmacokinetics and antitumor properties in tumor-bearing mice of an enediol analogue inhibitor of glyoxalase I.

Cancer chemotherapy and pharmacology·2000

Reaction mechanism of glyoxalase I explored by an X-ray crystallographic analysis of the human enzyme in complex with a transition state analogue.

Biochemistry·1999

Phosphoproteomics identifies PAK2-associated developmental modules in mouse embryos.

FEBS letters·2026

From junk to function - How weak selection in eukaryotes builds new parts and drives genomic complexity.

FEBS letters·2026

Stress-induced trained immunity-A key mechanism linking psychosocial stress, atherosclerosis, and cardiovascular disease.

FEBS letters·2026

Translophagy-A potential link between autophagy impairment and translational errors.

FEBS letters·2026

Engineering peptides into antibodies-opportunities and strategies for therapeutic innovation.

FEBS letters·2026

Emerging experimental and computational methods for studying redox-regulated structural transitions.

FEBS letters·2026

Trigeminal neuroplasticity after pulpitis and oral administration ofparacetamol in rats.

Acta odontologica latinoamericana : AOL·2026

Hypotonicity-Induced WNK1 Phosphorylation Prevents H2O2-Induced Apoptosis in Vascular Smooth Muscle Cells.

Basic & clinical pharmacology & toxicology·2026

Dynamic Axial Ligand Dissociation Drives Solvent Trapping and Solvation-Shell Reconstruction for Ultra-Long-Life Aprotic Zinc Batteries.

ACS nano·2026

A Gradient-Corrected Polarizable Continuum Model for Improved Reaction Fields at the SCF Level.

Journal of chemical theory and computation·2026

Symmetry-Adapted Relaxation Theory (SART): Variational Embedding for Convergent Infinite-Order Induction without Overpolarization.

Journal of chemical theory and computation·2026

Efficient Computation of Physical Charging Free Energies for Monatomic Ions at Any Charge along Alchemical Charging Pathways.

Journal of chemical theory and computation·2026

Related Experiment Videos

Solvent isotope effects on tautomerization equilibria of papain and model thiolamines

Related Concept Videos

Glyoxalase I inhibitors in cancer chemotherapy.

Brief history of glyoxalase I and what we have learned about metal ion-dependent, enzyme-catalyzed isomerizations.

Role of hydrophobic interactions in binding S-(N-aryl/alkyl-N-hydroxycarbamoyl)glutathiones to the active site of the antitumor target enzyme glyoxalase I.

Reaction of COTC with glutathione: structure of the putative glyoxalase I inhibitor.

Pharmacokinetics and antitumor properties in tumor-bearing mice of an enediol analogue inhibitor of glyoxalase I.

Reaction mechanism of glyoxalase I explored by an X-ray crystallographic analysis of the human enzyme in complex with a transition state analogue.

Phosphoproteomics identifies PAK2-associated developmental modules in mouse embryos.

From junk to function - How weak selection in eukaryotes builds new parts and drives genomic complexity.

Stress-induced trained immunity-A key mechanism linking psychosocial stress, atherosclerosis, and cardiovascular disease.

Translophagy-A potential link between autophagy impairment and translational errors.

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Emerging experimental and computational methods for studying redox-regulated structural transitions.

Trigeminal neuroplasticity after pulpitis and oral administration ofparacetamol in rats.

Hypotonicity-Induced WNK1 Phosphorylation Prevents H2O2-Induced Apoptosis in Vascular Smooth Muscle Cells.

Dynamic Axial Ligand Dissociation Drives Solvent Trapping and Solvation-Shell Reconstruction for Ultra-Long-Life Aprotic Zinc Batteries.

A Gradient-Corrected Polarizable Continuum Model for Improved Reaction Fields at the SCF Level.

Symmetry-Adapted Relaxation Theory (SART): Variational Embedding for Convergent Infinite-Order Induction without Overpolarization.

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Solvent isotope effects on tautomerization equilibria of papain and model thiolamines

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