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Lung deformations at minimal volume

M J Kallok, S J Lai-Fook

    Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology
    |March 1, 1980
    PubMed
    Summary
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    Minimal lung volume was greater in saline-filled lobes than air-filled lobes. Gravitational deformation significantly impacts air-filled lung volume measurements, affecting minimal volume (MV) determination.

    Area of Science:

    • Pulmonary Physiology
    • Respiratory Mechanics
    • Biophysics

    Background:

    • Accurate determination of minimal lung volume (MV) is crucial for understanding respiratory mechanics.
    • Previous studies have not fully accounted for the influence of gravity on excised lung preparations.

    Purpose of the Study:

    • To investigate the effect of gravitational deformation on minimal lung volume (MV) in excised dog lobes.
    • To compare MV in lobes inflated with air versus saline.
    • To analyze the role of gravity in the discrepancy between air and saline MV.

    Main Methods:

    • Excised dog lobes were inflated with either air or saline.
    • Minimal volume (MV) was measured at zero transpulmonary pressure.
    • Lobes were subjected to different gravitational deformations (supported vs. hung).

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  • Linear elasticity principles were applied to model gravitational effects.

    • Main Results:

    • Saline-filled lobes exhibited a significantly greater MV than air-filled lobes.
    • MV was significantly greater in hung lobes compared to supported lobes.
    • Gravitational deformation was identified as a key factor influencing MV in air-filled lungs.

    Conclusions:

    • The difference in MV between saline and air inflation is primarily attributed to gravitational deformation of air-filled lungs.
    • Gravity significantly alters the volume of excised lungs, particularly when filled with air.
    • Careful consideration of gravitational effects is necessary for accurate MV measurements in lung research.