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Related Experiment Video

Updated: Jul 24, 2026

Mouse Model of Pressure Ulcers After Spinal Cord Injury

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Published on: March 9, 2019

Drug-based prevention of pressure-sores

A A Barton, M Barton

Lancet (London, England)

|August 21, 1976

Summary

Adrenocorticotropic hormone (ACTH) administration reduced pressure sore incidence in hip surgery patients. This intervention is recommended for high-risk surgical scenarios to improve patient outcomes.

Area of Science:

Surgical patient care
Wound healing research
Endocrinology in surgery

Background:

Pressure sores are a common complication in patients undergoing hip and femur surgery.
Effective prevention strategies are crucial for improving patient recovery and reducing healthcare costs.

Purpose of the Study:

To evaluate the efficacy of Adrenocorticotropic Hormone (ACTH) in preventing pressure sores in patients undergoing hip and femur surgery.
To compare the incidence of pressure sores between a control group and a group receiving ACTH treatment.

Main Methods:

A double-blind clinical trial involving 85 patients undergoing upper femur or hip-joint surgery.
Administration of 80 IU of ACTH in a gelatin solvent to the treatment group.
Comparison of pressure sore development rates between the ACTH group and the control group.

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Main Results:

The incidence of pressure sores was 27% in the control group compared to 12% in the ACTH-treated group.
In patients with femur shaft fractures, 19% developed sores, potentially due to timing challenges with ACTH administration.
Complete prevention was observed in total-hip replacement cases, where ACTH timing was optimal.

Conclusions:

ACTH administration significantly reduces the incidence of pressure sores in high-risk surgical patients, particularly in elective procedures like total-hip replacement.
Optimizing the timing of ACTH administration is key to maximizing its preventive effects.
The study suggests incorporating ACTH into the management protocols for high-risk surgical situations.