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Related Experiment Videos

Carcinoid disease

E R Wood, W G Wood

    Southern Medical Journal
    |May 1, 1980
    PubMed
    Summary
    This summary is machine-generated.

    Carcinoid tumors in the small intestine often metastasize, requiring chemotherapy for liver involvement. However, carcinoid tumors of the appendix, rectum, and lung show excellent outcomes with surgical excision alone.

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    Area of Science:

    • Gastroenterology
    • Oncology
    • Pathology

    Background:

    • Carcinoid tumors are neuroendocrine neoplasms with varied origins and clinical behaviors.
    • Understanding the metastatic potential and treatment outcomes for different carcinoid tumor sites is crucial for patient management.

    Observation:

    • A review of 28 carcinoid tumor cases diagnosed between 1967 and 1977.
    • Tumor sites included the small intestine (11), appendix (8), rectum (3), and lung (6).
    • Carcinoid syndrome was observed in 3 patients with small bowel tumors and liver metastases.

    Findings:

    • Small intestinal carcinoids frequently metastasized, often multicentrically.
    • Surgical excision alone was effective for localized disease without distant metastases.
    • Advanced disease with liver involvement had a poor prognosis without chemotherapy.

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  • Carcinoid tumors of the appendix, rectum, and lung did not recur or metastasize after surgery.
  • Six patients developed secondary neoplasms, suggesting a neoplastic diathesis in carcinoid patients.

    • Implications:

    • Early surgical intervention is key for localized carcinoid tumors.
    • Chemotherapy is essential for managing metastatic carcinoid syndrome, particularly with liver involvement.
    • The association with other neoplasms highlights the need for long-term surveillance in carcinoid patients.