Iotroxamide--a new cholangiographic agent. Relation between plasma concentration and biliary excretion in man

The relationship between infusion rates, plasma concentration and biliary excretion of iotroxamide were studied in 24 patients with a T-tube in situ. Plasma iotroxamide concentration was linearly related to the rate of infusion over a dose range of 0.525 to 6.3 mg/kg/min. Peak biliary concentrations and excretory rates of iotroxamide were seen when the plasma concentration was of the order of 1500 microgram/ml. The results suggest that when using a one hour infusion of iotroxamide near optimal concentrations of iodine in the bile duct can be achieved with an infusion rate of around 4 mg/kg/minute. No toxic effects were noticed from the use of this new cholangiographic agent.