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Electron microscopy in iris nevus syndrome

M K Khalil, M H Finlayson

    Canadian Journal of Ophthalmology. Journal Canadien D'Ophtalmologie
    |January 1, 1980
    PubMed
    Summary
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    Iris nevus syndrome can lead to secondary glaucoma and cataracts. Electron microscopy revealed ectopic corneal endothelium on the iris, suggesting iris abnormalities are often a reactive response in this condition.

    Area of Science:

    • Ophthalmology
    • Pathology
    • Electron Microscopy

    Background:

    • Iris nevus syndrome is a rare condition characterized by iris and choroidal nevi.
    • Patients may develop secondary glaucoma and cataracts.
    • This study examined iris tissue from a patient with iris nevus syndrome and co-existing glaucoma and cataract.

    Observation:

    • Electron microscopy was used to examine iris tissue obtained during cataract extraction.
    • The iris sector was found to be covered by ectopic corneal endothelium.
    • An atypical Descemet's membrane was observed beneath the ectopic endothelium.

    Findings:

    • Abnormalities in the iris stroma included aggregates of melanophagic cells.
    • Fibrosis was noted in the iris, associated with the ectopic endothelium.

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  • These pathological findings provide insight into the structural changes in the iris.

    • Implications:

    • The observed ectopic corneal endothelium and associated iris changes suggest a reactive process.
    • These findings may help elucidate the pathogenesis of iris abnormalities in iris nevus syndrome.
    • Understanding these reactive changes could inform future management strategies for affected individuals.