Is tubulin involved in the electrically-induced mechanical activity of the isolated rat sciatic nerve?

The electrically-induced mechanical activity of isolated segments of rat sciatic nerves remains unaffected following incubation with 10(-4) M colchicine, vinblastine or melatonin. Vinblastine depressed tubulin levels in incubated nerves. These results suggest that microtubules are not involved in nerve mechanical activity in vitro.