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Multicentric giant-cell tumor of bone
The Journal of Bone and Joint Surgery. American Volume
|January 1, 1980
Summary
Multicentric giant-cell tumors of bone, though rare, often affect the hands. Surgical excision is recommended, as curettage, especially in the hand, frequently leads to recurrence.
Area of Science:
- Orthopedic Oncology
- Bone Pathology
- Surgical Pathology
Background:
- Primary multicentric giant-cell tumor of bone is a rare condition.
- Previous reports are limited, with only fifteen cases documented.
Purpose of the Study:
- To report on a series of five patients with primary multicentric giant-cell tumor of bone.
- To analyze the clinical course, histological features, and treatment outcomes of these rare bone tumors.
Main Methods:
- Retrospective follow-up of five patients (eighteen lesions) over 4 to 14.5 years.
- Review of clinical data, histological findings, and treatment modalities including excision, curettage, bone-grafting, amputation, and en bloc resection.
Main Results:
- High incidence of lesions in small bones of the hand (11/18).
- Histological features were typical, with some showing spindle cell stroma.
- Recurrence rates varied by treatment: 4/5 patients recurred after excision, 6/8 after curettage (all hand lesions recurred), and 1/ lesions after amputation/en bloc resection.
- One infection, no metastases observed.
Conclusions:
- Multicentric giant-cell tumors of bone behave similarly to monostotic tumors.
- Surgical excision, particularly amputation or en bloc resection, is associated with lower recurrence rates.
- Curettage, especially for hand lesions, has a high recurrence rate.