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The antifertility action of alpha-chlorohydrin: enzyme inhibition by alpha-chlorohydrin phosphate
Experientia
|October 15, 1978
Abstract:
Preparations of the enzymes glyceraldehyde-3-phosphate dehydrogenase and triosephosphate isomerase are shown to be inhibited by alpha-chlorohydrin phosphate (II) in a competitive and non-competitive manner, respectively. alpha-Chlorohydrin (I), glycidol and epi-chlorohydrin have no inhibitory activities suggesting that their antifertility actions are due to their metabolism in vivo to alpha-chlorohydrin phosphate.