[Drug permeation through synthetic lipid membranes. Part 10: The effects of diffusion layers on the permeation...

Two different processes take their courses during the permeation of substances through lipid membranes. The substance must pass across the diffusion layers on the membranes and also across the lipid barrier proper. The effects of these two processes on the permeation vary with the kind of the membrane and of the substance as well as with the diffusion layer thickness which is determined by the intensity of movement. Correlations have been established which permit to calculate diffusion layers, membrane permeation coefficients, and also diffusion coefficients in the diffusion layers. Thus have been provided the prerequisites for the comparison of results obtained on using different model parameters.