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Cardiac function in primary hypothyroidism

J T Hayford, R M Schieken, R G Thompson

    American Journal of Diseases of Children (1960)
    |June 1, 1980
    PubMed
    Summary
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    Children with primary hypothyroidism did not show cardiac abnormalities. Thyroxine therapy resolved small pericardial effusions, but no evidence of cardiac compromise was found in these pediatric patients.

    Area of Science:

    • Pediatric Cardiology
    • Endocrinology
    • Thyroid Disorders

    Background:

    • Primary hypothyroidism in children can affect cardiac function.
    • Pericardial effusions are a potential complication of hypothyroidism.
    • The impact of hypothyroidism on pediatric cardiac structure and function requires clarification.

    Purpose of the Study:

    • To assess cardiac chamber dimensions and myocardial function in children with primary hypothyroidism.
    • To evaluate the effects of thyroxine therapy on cardiac parameters and pericardial effusions.
    • To determine if a cardiomyopathy exists in pediatric hypothyroidism.

    Main Methods:

    • Echocardiographic assessment of cardiac dimensions and myocardial function.
    • Evaluation of systolic time intervals and contractility indices.

    Related Experiment Videos

  • Comparison of pre- and post-thyroxine therapy measurements in 15 children.

    • Main Results:

    • Small pericardial effusions were present in 11/15 children, resolving in 9 after thyroxine therapy.
    • No significant abnormalities in cardiac dimensions or myocardial function were detected compared to controls.
    • Thyroxine replacement did not significantly alter myocardial dimensions or contractility.

    Conclusions:

    • Hypothyroidism in children does not appear to cause significant cardiac chamber or myocardial abnormalities.
    • Pericardial effusions in pediatric hypothyroidism are generally small and resolve with treatment.
    • The data refute the existence of a specific cardiomyopathy associated with childhood hypothyroidism.