Related Experiment Video

Updated: Jul 31, 2026

Integrated Compensatory Responses in a Human Model of Hemorrhage
07:57

Integrated Compensatory Responses in a Human Model of Hemorrhage

Published on: November 20, 2016

Response of systemic arterial input impedance to volume expansion and hemorrhage

J P Dujardin, D N Stone, L T Paul

    The American Journal of Physiology
    |June 1, 1980
    PubMed

    More Related Videos

    Description of a Swine Infant Model of Volume-Controlled Hemorrhagic Shock09:09

    Description of a Swine Infant Model of Volume-Controlled Hemorrhagic Shock

    Published on: November 3, 2023

    A New Hybrid Quantitative Evaluation Model for Axillary Junctional Hemorrhage in Swine08:27

    A New Hybrid Quantitative Evaluation Model for Axillary Junctional Hemorrhage in Swine

    Published on: December 6, 2024

    Related Concept Videos

    Regulation of Stroke Volume01:27

    Regulation of Stroke Volume

    The regulation of stroke volume, which is the amount of blood the heart pumps out during each heartbeat, is critical for maintaining a healthy circulatory system. Stroke volume is influenced by three main factors: preload, contractility, and afterload.
    Preload refers to the degree of stretch on the heart before it contracts. It's analogous to the stretching of a rubber band; the more it's stretched, the more forcefully it snaps back. This concept is encapsulated in the Frank-Starling law of the...
    Vascular Resistance01:20

    Vascular Resistance

    Vascular resistance is a critical concept in understanding blood flow dynamics in the circulatory system. It refers to the resistance that blood encounters as it flows through the blood vessels. This resistance is a key factor in determining blood pressure and cardiac workload.
    The primary determinants of vascular resistance are vessel diameter, blood viscosity, and vessel length. Among these, vessel diameter plays the most significant role due to the fourth power relationship described by...
    Autoregulation of Blood Flow01:17

    Autoregulation of Blood Flow

    Autoregulation mechanisms are characterized by their inherent capacity for self-regulation without necessitating specific nervous stimulation or endocrine control. These mechanisms facilitate the adjustment of blood flow and, therefore, perfusion specific to each tissue region. This self-regulation encompasses chemical signals and myogenic controls.
    Chemical Signaling in Autoregulation
    Chemical signaling operates at the precapillary sphincter level, inciting either contraction or relaxation.
    Blood Pressure Imbalances and Circulatory Shock01:24

    Blood Pressure Imbalances and Circulatory Shock

    Disorders affecting blood volume, vascular tone, or vascular function can disrupt vascular homeostasis, including conditions like hypertension, hemorrhage, and shock.
    Blood Pressure: Hypertension and Hypotension
    Normal blood pressure is 120/80 mm Hg. Elevated blood pressure is 120-129/under 80 mm Hg. Hypertension, warranting treatment at 130/80 mm Hg, is often asymptomatic and can lead to severe cardiovascular events, aneurysms, peripheral arterial disease, chronic renal disease, or cardiac...
    Cardiac Output II: Effect of Stroke Volume on Cardiac Output01:22

    Cardiac Output II: Effect of Stroke Volume on Cardiac Output

    Cardiac output (CO), the amount of blood the heart pumps per minute, is a parameter in cardiovascular physiology determined by stroke volume and heart rate. Stroke volume, the amount of blood pushed from one of the ventricles per heartbeat, is influenced by preload, afterload, and contractility.
    Preload
    Preload refers to the initial elongation of the cardiac myocytes before contraction and is related to the volume of blood filling the heart at the end of diastole, or end-diastolic volume. The...
    Hemorrhagic Stroke ll: Pathophysiology01:29

    Hemorrhagic Stroke ll: Pathophysiology

    A hemorrhagic stroke develops when a cerebral blood vessel ruptures, allowing blood to escape into the surrounding brain tissue, as in intracerebral hemorrhage (ICH), or into the subarachnoid space, as in subarachnoid hemorrhage (SAH). Because the skull is a rigid compartment, the sudden presence of extravascular blood rapidly increases intracranial pressure and compresses adjacent neural structures, leading to immediate tissue injury and impaired cerebral perfusion.Mass Effect and Primary...