Production of carrier-free 18F-labeled acetic acid via a recoil labeling method

Via recoil activation, carrier-free 18F-labeled acetic acid can be produced by the irradiation of a mixture of glacial acetic acid and potassium fluoride. The labeling yield seems to be high enouth to produce this compound with activity amounts suitable for nuclear medical investigation. Using a mixture of glacial acetic acid and freon-11, 18F-labeled acetic acid could be found. This system is assumed to be more applicable for the production of other 18F-labeled carboxylic acids. Under optimized irradiation conditions we expect to produce some mCi of labeled monofluoroacetic acid.