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Continuous Manual Exchange Transfusion for Patients with Sickle Cell Disease: An Efficient Method to Avoid Iron Overload
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[Therapy of juvenile iron deficiency with bivalent iron dragees (Fe2-fumarate, succinate, sulfate). Controlled

C Bender-Götze

    Fortschritte Der Medizin
    |April 17, 1980
    PubMed

    Insights

    Different iron salts showed similar effectiveness in treating moderate iron deficiency in children. Liquid iron preparations are recommended for children over two due to tablet refusal.

    Area of Science:

    • Pediatric Hematology
    • Nutritional Science
    • Pharmacology

    Background:

    • Iron deficiency is a common nutritional disorder in children.
    • Divalent iron salts are frequently prescribed for iron repletion.
    • Assessing the comparative efficacy and tolerability of different iron salt formulations is crucial for pediatric treatment.

    Purpose of the Study:

    • To compare the efficacy and gastrointestinal side effects of three different divalent iron salts (fumarate, succinate, sulfate) versus placebo in children with moderate iron deficiency.
    • To evaluate the optimal preparation form for iron supplementation in different pediatric age groups.

    Main Methods:

    • A controlled, double-blind study was conducted with 53 children diagnosed with moderate iron deficiency (hemoglobin levels between 7.5 to 12 g/dL).
    • Children received either iron(II) fumarate, iron(II) succinate, or iron(II) sulfate tablets, or a placebo.
    • Therapeutic success was measured by hemoglobin regeneration, and gastrointestinal side effects were systematically recorded.

    Main Results:

    • No significant difference in therapeutic success (hemoglobin regeneration) was observed among the three iron salts tested.
    • All tested iron salts were significantly more effective than placebo in improving hemoglobin levels.
    • Gastrointestinal side effects were more frequent with iron succinate (50%) and iron sulfate (25%) compared to iron fumarate and placebo.
    • Children over two years of age demonstrated a significant refusal rate for tablet administration.

    Conclusions:

    • Divalent iron salts (fumarate, succinate, sulfate) demonstrate comparable efficacy in treating moderate iron deficiency in children.
    • Iron fumarate may be preferable due to a potentially lower incidence of gastrointestinal side effects compared to succinate and sulfate.
    • Liquid iron preparations are recommended for children over two years to improve adherence and compliance.

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