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Related Experiment Videos

Demonstration and quantification oomycosis

L Yarzábal, J P Dessaint, M Arango

    International Archives of Allergy and Applied Immunology
    |January 1, 1980
    PubMed
    Summary

    This study found elevated total and specific immunoglobulin E (IgE) against Paracoccidioides brasiliensis in patients with paracoccidioidomycosis. These findings suggest IgE

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    Area of Science:

    • Immunology
    • Mycology
    • Infectious Diseases

    Background:

    • Paracoccidioidomycosis is a systemic fungal infection endemic to Latin America.
    • The role of immunoglobulin E (IgE) in the immune response to Paracoccidioides brasiliensis is not fully understood.
    • Elevated IgE levels are observed in various allergic and infectious conditions.

    Purpose of the Study:

    • To quantify total and specific IgE levels against Paracoccidioides brasiliensis in patients with active paracoccidioidomycosis.
    • To compare IgE levels in paracoccidioidomycosis patients with those in patients with other mycoses and healthy individuals.
    • To investigate the potential involvement of specific IgE in the pathogenesis of paracoccidioidomycosis.

    Main Methods:

    • Radioimmunoassay (RIA) technique was employed to measure total and specific IgE.
    • Sera from patients with confirmed paracoccidioidomycosis were analyzed.
    • Control groups included patients with aspergilloma, Candida albicans antibodies, and healthy individuals from endemic areas.

    Main Results:

    • Significantly elevated total IgE levels were observed in 9 out of 10 paracoccidioidomycosis patients.
    • Mean specific IgE levels against P. brasiliensis were significantly higher in patients compared to controls.
    • The percentage of specific IgE relative to total IgE ranged from 0.38% to 2.28%.

    Conclusions:

    • Specific IgE antibodies against P. brasiliensis may play a role in the immune response to paracoccidioidomycosis.
    • Hyperimmunoglobulinemia E in paracoccidioidomycosis could be linked to T-cell defects observed in severe disease forms.
    • Further research is warranted to elucidate the precise function of IgE in paracoccidioidomycosis.

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