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A computer-based toxicology search system

J R McGill, S R Heller, G W Milne

    Journal of Environmental Pathology and Toxicology
    |November 1, 1978
    PubMed
    Summary
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    A new interactive computer system allows users to search the National Institute for Occupational Safety and Health

    Area of Science:

    • Toxicology
    • Computational Chemistry
    • Information Science

    Background:

    • The National Institute for Occupational Safety and Health (NIOSH) maintains a Registry of Toxic Effects of Chemicals (RTECS).
    • Accessing and retrieving specific toxicity data from large chemical databases can be challenging.
    • There is a need for efficient tools to query chemical toxicity information.

    Purpose of the Study:

    • To develop an interactive computer search system for accessing the NIOSH Registry of Toxic Effects of Chemicals (RTECS).
    • To enable retrieval of detailed toxicity data based on various parameters.
    • To provide a user-friendly interface for chemical toxicity information.

    Main Methods:

    • Development of an interactive computer search system.

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  • Integration with the NIOSH Registry of Toxic Effects of Chemicals (RTECS) database.
  • Implementation of search functionalities based on compound identity, test animal, dosage, and toxicity level.
  • Utilizing Chemical Abstracts Service (CAS) Registry Number and RTECS Accession Number for compound identification.

    • Main Results:

    • An operational interactive computer search system has been successfully developed.
    • The system allows for the retrieval of specific toxicity data for chemical substances.
    • Users can search for all available toxicity data using compound name, structure, CAS Registry Number, or RTECS Accession Number.

    Conclusions:

    • The developed system provides efficient access to the NIOSH-RTECS toxicity database.
    • The system is accessible via an international computer network on a fee-for-service basis.
    • This tool facilitates easier retrieval and utilization of chemical toxicity information for researchers and professionals.