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Related Experiment Videos

D-penicillamine-induced bronchial spasm

K Tanphaichitr

    Southern Medical Journal
    |June 1, 1980
    PubMed
    Summary
    This summary is machine-generated.

    D-penicillamine can cause serious airway obstruction, even with careful dosing. This case highlights the need for vigilance against potentially fatal side effects like bronchial spasm and angioedema.

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    Area of Science:

    • Pharmacology
    • Pulmonology
    • Clinical Medicine

    Background:

    • D-penicillamine is a chelating agent with diverse clinical applications.
    • Reported side effects can limit its therapeutic use.
    • Standard dosing regimens aim to minimize adverse events.

    Observation:

    • A patient developed reversible airway obstruction despite a "go slow--go low" d-penicillamine regimen.
    • Symptoms of bronchial spasm and angioedema occurred after a dose increase.
    • This reaction was observed despite adherence to a cautious titration schedule.

    Findings:

    • D-penicillamine can induce significant, reversible airway obstruction.
    • Bronchial spasm and angioedema are potential acute adverse reactions.
    • The "go slow--go low" approach did not prevent this specific side effect.

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    Implications:

    • Clinicians must maintain high vigilance for severe adverse reactions to d-penicillamine.
    • Careful monitoring is crucial, even with dose escalation protocols.
    • Prompt recognition and management are essential to prevent potentially fatal outcomes.