The metabolism of oxamniquine in the gut wall

1. The extent of metabolism of oxamniquine, 6-hydroxymethyl-7-nitro-2-isopropylaminomethyl-1,2,3,4-tetrahydroquinoline, in the gut of the dog has been studied using an intestinal preparation which allows collection of the outflow from the portal vein. 2. Oxamniquine undergoes substantial conversion to 2-isopropylaminomethyl-7-nitro-1,2,3,4,-tetrahydroquinoline-6-carboxylic acid before or during absorption. 3. This oxidation is not significantly inhibited by pretreatment with pyrazole, erythromycin or gentamicin. 4. Results indicate that appreciable oxidation of oxamniquine is mediated via enzymes in the gut wall.