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[Interaction between lactobacilli and the intestinal mucosa]

N P Tarabrina

    Zhurnal Mikrobiologii, Epidemiologii I Immunobiologii
    |January 1, 1980
    PubMed
    Summary

    Lactobacilli normally colonize the mouse intestine, closely associating with the mucosa. Radiation-induced dysbacteriosis weakens this association, reducing mucosal lactobacilli by tenfold.

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    Area of Science:

    • Microbiology
    • Gastroenterology
    • Radiation Biology

    Background:

    • Lactobacilli are key gut commensals influencing host health.
    • Intestinal dysbacteriosis, often caused by radiation, disrupts microbial balance.
    • Understanding lactobacilli-mucosa interactions is crucial for gut health research.

    Purpose of the Study:

    • To investigate lactobacilli distribution and mucosal adhesion in mice.
    • To compare these interactions under normal and postradiation dysbiosis conditions.

    Main Methods:

    • Studied lactobacilli distribution in the intestinal lumen and mucosa of CBA mice.
    • Assessed lactobacilli-mucosa association strength, including resistance to trypsin and detergents.
    • Induced experimental postradiation dysbacteriosis for comparative analysis.
    • Introduced exogenic streptomycin-resistant lactobacilli to assess mucosal colonization.

    Main Results:

    • Under normal conditions, lactobacilli were abundant in the lumen and mucosa throughout the intestine.
    • Lactobacilli showed strong mucosal adhesion, unaffected by trypsin or detergents.
    • Postradiation dysbiosis significantly weakened lactobacilli-mucosa association, decreasing mucosal counts 10-fold.
    • Exogenic lactobacilli demonstrated the capacity to colonize the intestinal mucosa.

    Conclusions:

    • Lactobacilli exhibit robust mucosal adhesion in healthy mice.
    • Radiation-induced dysbacteriosis severely impairs lactobacilli's ability to associate with the intestinal mucosa.
    • The intestinal mucosa remains a potential niche for exogenic lactobacilli even after dysbiosis.

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