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Prophylactic vitamin D in the elderly

K R Johnson, J Jobber, B J Stonawski

    Age and Ageing
    |May 1, 1980
    PubMed
    Summary
    This summary is machine-generated.

    Prophylactic vitamin D supplementation in the elderly showed short-term benefits in phosphate levels but did not improve muscle function. However, the risk of hypercalcemia limits its continuous use.

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    Area of Science:

    • Gerontology
    • Nutritional Biochemistry
    • Clinical Trials

    Background:

    • Elderly populations are susceptible to vitamin D deficiency.
    • Prophylactic vitamin D is often considered for bone health and overall well-being in older adults.

    Purpose of the Study:

    • To evaluate the effects of prophylactic vitamin D on biochemical markers and muscle function in an elderly population.
    • To assess the safety and efficacy of vitamin D supplementation in preventing phosphate level decline.

    Main Methods:

    • A double-blind, placebo-controlled trial was conducted on elderly subjects.
    • Clinical assessments, physiotherapy tests for muscle function, and biochemical analyses were performed before and after supplementation.
    • Serum phosphate and 25-hydroxy-vitamin D levels were monitored.

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    Main Results:

    • A significant decrease in serum phosphate was observed in the placebo group, particularly during winter months (October-March).
    • No significant fall in serum phosphate occurred in the vitamin D group.
    • No differences in muscle function were detected between the vitamin D and placebo groups.
    • Two participants in the vitamin D group developed hypercalcemia.

    Conclusions:

    • Vitamin D supplementation appears to improve phosphate status in the elderly short-term.
    • The risk of hypercalcemia associated with vitamin D administration at the tested levels prevents its continuous prophylactic use.
    • Further research may be needed to determine safe and effective prophylactic vitamin D dosages for the elderly.