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Updated: Aug 5, 2026
11:38
High Content Screening Analysis to Evaluate the Toxicological Effects of Harmful and Potentially Harmful Constituents (HPHC)
Published on: May 10, 2016
Coumarin-associated hepatitis. Report of two cases
Archives of Internal Medicine
|August 1, 1980
Summary
Recurrent jaundice cases suggest coumarin-induced hepatitis from phenprocoumon exposure. Hepatitis resolved upon drug withdrawal but recurred with reexposure, confirming drug-induced liver injury.
Area of Science:
- Hepatology
- Toxicology
- Internal Medicine
Background:
- Drug-induced liver injury (DILI) is a significant clinical concern.
- Phenprocoumon, a coumarin derivative, is widely used as an anticoagulant.
- Recurrent liver injury following drug exposure requires careful investigation.
Observation:
- Two patients presented with recurrent jaundice linked to phenprocoumon.
- Histological findings included cholestasis in one and chronic aggressive hepatitis in the other.
- Hepatopathy resolved after phenprocoumon cessation but recurred upon re-challenge.
Findings:
- Phenprocoumon exposure was strongly associated with recurrent hepatitis in both cases.
- Histological patterns varied, suggesting different injury mechanisms or stages.
- Rechallenge confirmed phenprocoumon as the causative agent for hepatopathy.
Implications:
- This highlights the importance of considering coumarin-induced hepatitis in patients with unexplained recurrent jaundice.
- Careful drug history and monitoring are crucial for anticoagulated patients.
- Understanding DILI mechanisms can guide management and prevention strategies.
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