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Related Experiment Videos

Ocular microbial flora in immunodeficient patients

M H Friedlaender, R J Masi, M Osumoto

    Archives of Ophthalmology (Chicago, Ill. : 1960)
    |July 1, 1980
    PubMed
    Summary

    Patients with primary immunodeficiency syndromes experienced more frequent external ocular infections. Microbial cultures revealed pathogens in infected patients, but lid and conjunctival flora did not differ from controls.

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    Area of Science:

    • Ophthalmology
    • Immunology
    • Microbiology

    Background:

    • Primary immunodeficiency syndromes (PIDs) can predispose individuals to infections.
    • Ocular adnexa are susceptible to microbial colonization and infection.

    Purpose of the Study:

    • To investigate the ocular microbial flora and infection incidence in patients with PIDs.
    • To correlate ocular infections with specific immunologic defects.

    Main Methods:

    • Microbial cultures of eyelids and conjunctivae were performed on 20 patients with PIDs.
    • Ocular findings and medical histories were reviewed.
    • Patients were compared to 20 age-matched controls.

    Main Results:

    • Nine patients had a history of recurrent external ocular infections; six had active blepharitis or blepharoconjunctivitis.

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  • Pathogenic bacteria were isolated from six patients with infection history; mixed pathogens from three others.
  • Patients with infections exhibited various immunodeficiencies, including impaired B-cell and T-cell immunity, phagocytic defects, and intact B-/T-cell function in one case.
  • Immunodeficient patients had a higher incidence of lid/conjunctival infection than controls, but microbial flora composition was similar.

    • Conclusions:

    • Patients with PIDs have an increased risk of external ocular infections.
    • Specific immunologic defects may predispose to ocular infections, though the overall microbial flora remains comparable to healthy individuals.