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Abstract:
The permeability coefficient of BLM to nystatin was measured as function of cholesterol content of membrane and KCL concentration of aqueous medium. The data obtained were used to demonstrate that leakage of metabolites from microorganisms cytoplasm induced by nystatin may be a result of "two-sided" effect of polyene. This eliminates the known contradication between "two-sided" formation of pores in BLM by nystatin and its "one-sided" biological effect.