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Related Experiment Videos

Decrease in speech pause times with treatment of endogenous depression

J F Greden, B J Carroll

    Biological Psychiatry
    |August 1, 1980
    PubMed
    Summary
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    Speech pause time, the silent interval between speech, is prolonged in depression. This study confirms that longer pause times in unipolar and bipolar depression decrease with treatment, serving as an objective marker for psychomotor retardation.

    Area of Science:

    • Neuroscience
    • Psychiatry
    • Speech-Language Pathology

    Background:

    • Speech pause time, the silent interval between phonations, was previously suggested as an objective measure of psychomotor retardation in unipolar depression.
    • Phonation times were reported as unchanged in previous studies.

    Purpose of the Study:

    • To replicate and expand findings on speech pause and phonation times in depressed patients.
    • To investigate the utility of speech pause time as a biomarker for depression.

    Main Methods:

    • Measured speech pause and phonation times in four unipolar (UP) and three bipolar (BP) depressed inpatients.
    • Speech was recorded during counting tasks and converted to paper prints using a voice-operated electrical relay.

    Main Results:

    Related Experiment Videos

    • Pause times were significantly longer during baseline medication-free periods compared to discharge.
    • Progressive decreases in pause time correlated with clinical improvement in both UP and BP patients.
    • In two cases, over 50% decrease in pause time was observed within days of treatment initiation.

    Conclusions:

    • Speech pause times are a valid objective measure of psychomotor retardation in both unipolar and bipolar depression.
    • Decreases in speech pause time with treatment indicate clinical improvement and recovery.
    • Early reductions in pause time may predict treatment response, similar to changes in REM sleep.