Interaction of the absorbable hemostatic agent (IP760) with aminoglycosidic antibiotics

The linear, crosslinked amylose-succinate hemostatic agent, IP760, has been evaluated for its interaction with aminoglycosidic antibiotics. The highly structured polymer appears to act as a cationic exchange resin which binds the basic aminoglycosides. Binding of these agents to IP760 is reversed by increased pH and/or increased ionic strength. Dialysis experiments demonstrated that 85 and 90% of the bound gentamicin was released at pH 7.5 and 8.0, respectively, over a period of 36 hr. Formation of the IP760-antibiotic complexes suggests potential medicinal use for hemostatis and slow release of the antibiotic for prophylaxis of postsurgical contamination or infection