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Related Experiment Videos

Bacteremia in private pediatric practice

M A Baron, H D Fink

    Pediatrics
    |August 1, 1980
    PubMed
    Summary
    This summary is machine-generated.

    Capillary white blood cell (WBC) counts can help identify infants with unexplained fever who may have bacteremia. Specific WBC criteria effectively distinguish high-risk infants needing blood cultures from those likely to recover without antibiotics.

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    Area of Science:

    • Pediatric Infectious Diseases
    • Clinical Pathology
    • Hematology

    Background:

    • Unexplained febrile illness in infants and toddlers poses diagnostic challenges.
    • Distinguishing bacteremia is crucial for timely antibiotic intervention and preventing complications.
    • Office-based diagnostic tools are needed to guide further testing like blood cultures.

    Purpose of the Study:

    • To evaluate the utility of capillary white blood cell (WBC) count and differential in identifying bacteremia in febrile infants and toddlers.
    • To determine specific WBC criteria predictive of bacteremia in this age group.
    • To assess the ability of these criteria to differentiate infants who require blood cultures from those who do not.

    Main Methods:

    • Retrospective analysis of 146 infants (3-24 months) with unexplained febrile illness.

    Related Experiment Videos

  • Capillary WBC count and differential performed in office practice.
  • Four criteria evaluated: WBC count ≥15,000/cu mm, segmented neutrophils ≥10,000/cu mm, band cells ≥500/cu mm, and total polymorphonuclear leukocytes ≥10,500/cu mm.

    • Main Results:

    • Bacteremia was confirmed in 8 out of 146 infants.
    • Seven of the 8 bacteremic infants met three or four of the defined WBC criteria.
    • Only 10 (7.2%) of the 138 non-bacteremic infants met the same criteria (P < .001).

    Conclusions:

    • Capillary WBC count and differential are valuable tools for risk stratification in febrile infants.
    • The established WBC criteria help identify infants with a higher likelihood of bacteremia.
    • This approach can guide decisions regarding blood cultures and early bacteriologic diagnosis, potentially avoiding unnecessary antibiotic treatment in low-risk infants.